SCOPE OF TESTING
Application of thermoanalytical methods in pharmaceutical analysis and technology, and application of infrared spectroscopic methods (FTIR and Raman spectroscopy) in the analysis of raw materials and medicinal products, more specifically:
- study of phase transformations
- study of crystalline substances
- eutectic detection
- research related to the occurrence of polymorphism
- identification of amorphous phases
- detection of abnormalities
- determination of solid dispersion system compositions
- detection of hydrates and solvates.
PUBLICATIONS
Publications that have been developed by using the research methods described:
1. Rojek B., Gazda M., Plenis A., FTIR, Raman spectroscopy and HT-XRD in compatibility study between naproxen and excipients. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2023, 302, 123048. https://doi.org/10.1016/j.saa.2023.123048
2. Rojek B., Wesołowski M., A combined differential scanning calorimetry and thermogravimetry approach for the effective assessment of drug substance-excipient compatibility. J Therm Anal Calorim 2023, 148, 845–858. https://doi.org/10.1007/s10973-022-11849-9.
3. Leyk E., Wesolowski M., The effect of cellulose derivatives on paracetamol crystallinity reduction. J Therm Anal Calorim 2022, 147, 10037–10048. https://doi.org/10.1007/s10973-022-11312-9.
4. Rojek B., Gazda M. Wesołowski M., Quantification of Compatibility Between Polymeric Excipients and Atenolol Using Principal Component Analysis and Hierarchical Cluster Analysis. AAPS PharmSciTech, 2022, 23, 3. https://doi.org/10.1208/s12249-021-02143-2.
5. Lech A., Garbacz P., Sikorski A., Gazda M., Wesołowski M., New Saccharin Salt of Chlordiazepoxide: Structural and Physicochemical Examination. Int J Mol Sci. 2022, 23(19), 12050. doi: 10.3390/ijms231912050.
6. Leyk E., Wesołowski M., Miscibility and Solubility of Caffeine and Theophylline in Hydroxypropyl Methylcellulose. Pharmaceutics 2021, 13, 1836. https://doi.org/10.3390/pharmaceutics13111836.
7. Rojek B., Wesołowski M., Compatibility study of theophylline with excipients using thermogravimetry supported by kinetic analysis. J Therm Anal Calorim, 2021, 143, 227–236. https://doi.org/10.1007/s10973-019-09235-z.
8. Garbacz P., Wesołowski M., Benzodiazepines co-crystals screening using FTIR and Raman spectroscopy supported by differential scanning calorimetry. Spectrochim Acta A Mol Biomol Spectrosc.2020, 234, 118242. doi: 10.1016/j.saa.2020.118242.
9. Garbacz P., Paukszta D., Sikorski A., Wesołowski M., Structural characterization of co-crystals of chlordiazepoxide with p-aminobenzoic acid and lorazepam with nicotinamide by DSC, X-ray diffraction, FTIR and Raman spectroscopy. Pharmaceutics, 2020, 12, 648.
10. Rojek B., Wesołowski M., DSC supported by factor analysis as a reliable tool for compatibility study in pharmaceutical mixtures. J Therm Anal Calorim 2019, 138, 4531–4539. https://doi.org/10.1007/s10973-019-08223-7.
11. Rojek B, Wesołowski M., FTIR and TG analyses coupled with factor analysis in a compatibility study of acetazolamide with excipients. Spectrochim Acta A Mol Biomol Spectrosc. 2019, 208, 285-293. doi: 10.1016/j.saa.2018.10.020.
12. Leyk E, Wesołowski M., Interactions Between Paracetamol and Hypromellose in the Solid State. Front Pharmacol. 2019, 10, 14. doi: 10.3389/fphar.2019.00014.
13. Rojek B., Suchacz B., Wesołowski M., Artificial neural networks as a supporting tool for compatibility study based on thermogravimetric data. Thermochimica Acta, 2018, 659, 222-231.
14. Saganowska P., Wesołowski M., DSC as a screening tool for rapid co-crystal detection in binary mixtures of benzodiazepines with co-formers. J. Therm. Anal. Calorim. 2018, 133, 785-795.
15. Garbacz, P., Wesołowski, M., DSC, FTIR and Raman Spectroscopy Coupled with Multivariate Analysis in a Study of Co-Crystals of Pharmaceutical Interest. Molecules 2018, 23, 2136. https://doi.org/10.3390/molecules23092136
PRICE LIST
The laboratory will perform analyses according to individual orders with adaptation to specific needs of contractors. The cost of the service is priced individually.
CONTACT
Edyta Leyk, Ph.D.
Department of Analytical Chemistry
Medical University of Gdańsk
al. Gen. J. Hallera 107
80-416 Gdańsk
Phone: 58 349 15 26
edyta.leyk@gumed.edu.pl
